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Frontier Pharma: Pain - Industry shared in News Research Report Health Articles | March 17, 2016
"The Report Frontier Pharma: Pain - Identifying and Commercializing First-in-Class Innovation provides information on pricing Brett Hundley Jersey , market analysis, shares, forecast, and company profiles for key industry participants. - "
Description
Large and Innovative Pipeline
The active pain pipeline is populated by 796 products across all stages of development UCLA Bruins Jersey , which exhibit a highly diverse range of molecular targets. GBI Research’s analyses identified 122 first-in-class programs in active development, constituting 13.6% of the pipeline and acting on 65 first-in-class molecular targets, indicating a high degree of innovation. This is in stark contrast to the pain therapeutics market, which has been largely characterized by only incremental product innovation over the last decade Patrick Mahomes Jersey , as most market segments continue to be dominated by long-established active pharmaceutical ingredients and the concomitant mechanisms of action. Moderate-to-severe pain continues to be dominated by opioids that are increasingly being reformulated to offer abuse-resistance, while mild pain is effectively treated with Non-Steroidal Anti-Inflammatory Drugs (NSAID). However, significant unmet needs remain, as chronic pain and some neuropathic pain subtypes do not respond well to existing therapies Texas Tech Red Raiders Jersey , which are not adequate to treat associated hypersensitization and do not align to the underlying molecular pathophysiological profile.
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Despite being mostly distributed in the early stages of development, first-in-class innovation is particularly concentrated on novel molecular targets that are aligned to the central sensitization associated with neuropathic pain, which is arguably the most debilitating and difficult-to-treat type of chronic pain. This gives them the potential to transform the future market by expanding the range of drug classes.
Highly Diversified Range of Innovative Programs in Early Pipeline and in Granted Patents
Pain is a complex and multifaceted disorder with a complex interplay between different pathological processes, and different pain subtypes exhibit distinct underlying etiologies and pathophysiologies. While technological advances and extensive research efforts have furthered the understanding of these complex underpinnings Shane Buechele Jersey , gaps remain. However, these insights have translated into the expanding pool of novel therapeutic targets, as reflected by the highly innovative pipeline. GBI Research’s proprietary analysis shows that early-stage, first-in-class programs exhibit a higher level of diversity with respect to novel therapeutic targets. The significant diversity in terms of targets is a reflection of the complex underpinnings of distinct pain subtypes. Although the pipeline continues to feature established therapies Brian Orakpo Jersey , the range of mechanisms of action employed by novel compounds is extremely diverse, with the vast majority residing in the Preclinical stage. This innovation and diversity is maintained throughout the pipeline from early- to late-stage development, although the degree of innovation diminishes from Phase II. Additionally, although NSAIDs and opioids remain th. Wholesale JerseysWholesale Authentic JerseysWholesale Jerseys ChinaWholesale Jerseys Free ShippingWholesale Custom JerseysWholesale NBA JerseysWholesale Cheap NBA JerseysWholesale Custom MLB JerseysWholesale Baseball Jerseysholesale NCAA College Jerseys